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Congratulations 2014 Swimmers!

Posted By Administration, Friday, June 27, 2014

Congratulations 2014 Swimmers!

Swimmers at Geoffrey Keller Memorial Open Water Swim held June 21, 2014

Swimmers at the Geoffrey Keller Memorial Open Water Swim held June 21, 2014 Raised more than $2000 to fund research better ways of managing Malignant Hyperthermia during surgery, to improve methods of detecting MH, and for MH awareness.  

Save the Date! Next Swim is June 13, 2015

Watch this space for information.

Links:


Geoffrey Warren Keller - 1986-2012

About the Geoffrey Keller Memorial Open Water

Swim held in honor of the late son of Curt and Kathy Keller to raise funds to research better ways of managing Malignant Hyperthermia during surgery, to improve methods of detecting MH, and for MH awareness. Presented by Marshall, IL, the Geoff Keller Group of MHAUS, and Illinois Department of Natural Resources at Lincoln Trail Lake, Lincoln Trail State Park 16985 E. 1350th Road, Marshall, Il 62441 Sanctioned by Illinois Masters Swimming Association (ILMSA) for United States Masters Swimming (USMS), Inc. USMS Sanction Number: 214-W002.

Rectangular 1.2 & 2.4 - Mile loop course marked by buoys, lifeguards, rowboats, rescue boards, and kayaks, officials, and/or other safety resources. In-water start, swim counter-clockwise around orange 8-foot tetrahedron turn buoy marks (with red guide buoys on straightaways), exit water with brief run on beach sand, and through finish chute. Course is subject to change if event day conditions warrant.

 

Tags:  memorial  swim 

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The Inaugural Geoffrey Keller Memorial Open Water Swim

Posted By Michael Wesolowski, Thursday, April 3, 2014

The Inaugural Geoffrey Keller Memorial Open Water Swim

Held in honor of the late son of Curt and Kathy Keller to support Malignant Hyperthermia awareness.

Presented by Marshall, IL, the Geoff Keller Group of MHAUS, and Illinois Department of Natural Resources.

Please share with people you know in areas near to: Chicago, Cincinnati, Indianapolis, Louisville, and St. Louis.

Learn more about Geoffrey Keller: http://my.mhaus.org/group/GeoffKeller

Sanctioned by Illinois Masters Swimming Association (ILMSA) for United States Masters Swimming (USMS), Inc. USMS Sanction Number: 214‐W002 



Tags:  illinois  swim  Tags: Geoff Keller 

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Eagle Pharmaceuticals' Exclusive Licensor Granted US Patent for Dantrolene in the Treatment of Heat Stroke

Posted By Michael Wesolowski, Thursday, April 3, 2014
"Eagle Pharmaceuticals' Exclusive Licensor Granted US Patent for Dantrolene in the Treatment of Heat Stroke"
on Tuesday, 01 April 2014 08:15

Eagle Pharmaceuticals, Inc. ("Eagle") (NASDAQ:EGRX) announced today that the United States Patent and Trademark Office has granted Patent No. 8,685,460 for the treatment of heat stroke with Eagle’s dantrolene sodium for injectable suspension (“dantrolene”). The patent issued today expires in 2023. Eagle’s dantrolene formulation for the treatment of Exertional Heat Stroke (EHS) was granted Orphan Drug designation by the Food and Drug Administration on September 25, 2012.

Eagle is currently developing dantrolene in this new EHS indication. The company filed an NDA in January 2014 for Ryanodex® (dantrolene sodium-for injectable suspension) in the treatment of Malignant Hyperthermia (“MH”) which was granted a priority review and has a PDUFA date of July 22, 2014. Ryanodex for the treatment of MH has also received Orphan Drug designation.
EHS is one of the top three causes of sudden death among student athletes and is a leading cause of non-combat death within the US Military. Currently, there are no FDA approved drugs for the treatment of EHS. The current standard of care in treating heat stroke patients is aggressive cooling e.g. through icing and intravenous hydration. It is estimated that there are 30,000 cases of heat stroke every year in the US. Scott Tarriff, Eagle’s CEO, said, “This is the fourth patent issued to Eagle regarding Ryanodex. Eagle now has 11 patents owned, licensed or issued covering its pipeline and an additional 10 patents filed with the US patent office.”

ABOUT EXERTIONAL HEAT STROKE
EHS is a state of extreme hyperthermia that occurs when heat generated by exercise in warm climates results in an elevated body temperature (above 104° F) due to failed thermoregulation that occurs when the body produces or absorbs more heat than it dissipates. Extreme temperature elevation and the resulting metabolic crisis can become a medical emergency that can result in disability or death.

Read more at: http://www.eagleus.com/news-media/dantrolene-ehs-patent

Tags:  dantrolene  eagle pharmaceuticals  heat stroke  ryanodex 

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Far Reaching New Information Concerning the Diagnosis and Management of MH and Exertional Heat Stroke

Posted By Michael Wesolowski, Thursday, April 3, 2014
"Far Reaching New Information Concerning the Diagnosis and Management of MH and Exertional Heat Stroke"
by Dr. Henry Rosenberg MD, CPE
Thursday, March 20, 2014

The views expressed in this posting are mine alone and do not necessarily represent the views of other professionals or Board Members of MHAUS.

A 'NEW' DANTROLENE?
In 1979 dantrolene was approved by the FDA for the treatment of Malignant Hyperthermia. Dantrium (dantrolene)  was developed by a small company  located in upstate New York called Norwich Eaton Pharmaceuticals.  Procter & Gamble Company (yes, the soap, detergent and household product company) acquired Norwich Eaton prior to the approval of the drug by the FDA. A major effort led by Mary Elizabeth Kolb, spearheaded the effort resulting in approval of the drug in record time.   Dantrolene  was instantly embraced by the anesthesia community as it was the only drug that was effective in treating and reversing MH. Many hundreds, if not thousands, of lives have been saved thanks to dantrolene.

EXERTIONAL HEAT STROKE AND MALIGNANT HYPERTHERMIA
I and others have often written about the possible relationship between exertional heat stroke (EHS) and MH.  There are isolated reports in the literature and presentations at meetings, (which often do not get published) demonstrating that some patients who develop exertional heat stroke harbor genetic changes that are found in MH susceptibles.  However, it has been difficult to identify  a significant number of patients who developed EHS and then were tested for MH susceptibility either by genetic tests or by the standard caffeine halothane contracture test.  A very recent publication in the journal Military Medicine by a group of French investigators associated with the French army who have been studying the problem of MH and heat stroke for several years, demonstrate that 138 of 295 patients (47%) who suffered heat stroke were determined to be MH susceptible, based on the European version of the caffeine halothane contracture test which has been shown to be both highly sensitive and specific in diagnosing MH susceptibility (Sagui et al. Military Medicine 179;342, 2014). Unfortunately, they did not report on the molecular genetics of these patients.  In addition, the muscle that was harvested for testing was not from the thigh, which is the agreed-upon standard site. However, several MH testing centers in Europe and the US have demonstrated, with a lesser number of patients, that  many who experienced  heat stroke also harbor MH related mutations in the ryanodine receptor gene.


Tags:  dantrolene  exertion  heat stroke  henry rosenberg  mhaus blog 

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Thank You for Your Donation!

Posted By Michael Wesolowski, Thursday, December 26, 2013

Thank you very much for your generous donations. Your gifts will be used to support in part the MH Hotline, education, outreach, and research.

For example at the MH Scientific Conference held in Toronto, Canada in November, 100 doctors from a half a dozen countries met to share research they are working on during the two day Conference. Keynote Speaker, Dr. Wayne Chen of the University of Calgary, made a very interesting presentation on the Mechanisms and Treatment of RYR-associated Diseases. For more information about the Conference click this link.

Thank you again for generosity and look forward to meeting up with you at future events such as the upcoming Geoffrey Keller Memorial Open Water Swim in June.

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Organ Concert Now Being Planned

Posted By MHAUS, Friday, December 13, 2013
An organ concert is now being planned to learn more and how you can help, please contact Curt Keller.

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Geoff Keller formed.

Posted By MHAUS, Tuesday, October 23, 2012
Geoff Keller Group formed today!

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