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The MH Knowledge Bank is a blog that contains answers to questions about Malignant Hyperthermia. To comment on a post you need to sign in with your MHAUS membership; click Membership above for details. Search the Knowledge Bank for answers by entering key words of your question in the search box below. To ask a question click on Group Home above.

 

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Top tags: 5041495  dantrolene  rectal  cold IV  cooling  emw  foley  hyperkalemia  mixing  pediatric  3813866  3987098  3989667  4003984  4041716  4053516  4067821  4079923  4080719  5044179  5086854  5120488  5749934  adults  bacteriostatic  baralyme  blanket  breathing circuit  burns  calcium 

Is Isaac's Syndrome (neuromytonia) associated with MH?

Posted By Administration, Thursday, March 12, 2015

Answer:

Isaacs syndrome is not associated with MH. Inhalationals are likely safe, and since it’s a myotonia, you may get an exaggerated response from succinylcholine.

Reference # 5718535

Tags:  Isaac's Syndrome  neuromytonia 

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Is continuous temperature monitoring recommended for general anesthetics utilizing TIVA where there is no chance of exposure to a triggering agent?

Posted By Administration, Thursday, March 12, 2015

Answer:

All patients should be monitored for temperature unless the patient or the situation makes such monitoring impractical or unobtainable. An example of such would be endoscopy or colonoscopy wherein such monitoring may be more stimulating that the procedure.

Reference # 5739109

Tags:  colonoscopy  endoscopy  temperature monitoring  tiva 

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Is Charcot Marie Tooth Disease (unknown type) associated with MH?

Posted By Administration, Thursday, March 12, 2015

Answer:

There is no association between CMT and MH. Only sporadic mutation that occur in the general population; therefore VERY rare.

Reference # 5749934

Tags:  5749934  charcot marie tooth disease 

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What are suggestions for length of observation in a patient who has isolated Massater Muscle Spasm after Suxamethonium chloride (INN), also known as suxamethonium or but no other signs of MH?

Posted By Administration, Monday, December 8, 2014
Updated: Monday, December 22, 2014

Answer:

Observe the patient for several hours AFTER the patient is awake and demonstrating no other signs or symptoms of MH. Normal laboratory tests such as CPK, K+ are helpful as well. If uncertain, it is a good idea to admit the patient and observe over night when unsure.

Reference #  5120488

Tags:  5120488  massater  massater muscle spasm  succinylcholine  suxamethonium  suxamethonium chloride 

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Does MHAUS have any recommendations regarding Ryanodex?

Posted By Administration, Tuesday, December 2, 2014
Updated: Monday, December 22, 2014

Answer:

MHAUS recommends all preparations of dantrolene including Ryanodex from Eagle Pharmaceuticals; Dantrium IV from Parr Pharmaceutical; and Revonto from US WorldMeds. No preparation is favored over another.


Tags:  5086854  Dantrium IV  dantrolene  Eagle Pharmaceuticals  Parr Pharmaceutical  Revonto  Ryanodex  US WorldMeds 

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Can dantrolene be administered via intraosseous?

Posted By Administration, Monday, November 24, 2014
Updated: Monday, December 22, 2014

Answer:

No data exists on the effectiveness of any of the dantrolene products when administered via the intraosseous route. However, in the event that the patient is experiencing an acute MH event, and intravenous access can not be secured, it would be prudent to administer the dantrolene intraosseous in an attempt to get it into the patient to treat the MH episode.

Tags:  5044179  dantrolene  intraosseous 

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How long does the dantrolene solution stay stable in the syringe once mixed?

Posted By Michael Wesolowski, Monday, November 24, 2014
Updated: Monday, December 22, 2014

Answer:

Manufacturers say: 6 hours.

Tags:  5041495  dantrolene  mixing  syringe 

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What is a safe and quick way to cool a patient and reduce ice burns on the skin?

Posted By Administration, Monday, November 24, 2014
Updated: Monday, December 22, 2014

Answer:

Cotton cloths covered with cold water and ice. Can also do gastric lavage, infusion of cold IV solution, etc

Tags:  5041495  burns  cold IV  cooling  gastric lavage  ice 

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How to record accurate esophageal temperature with OG/NG tube is in place and the patient is being lavaged, along with the foley catheter?

Posted By Administration, Monday, November 24, 2014
Updated: Monday, December 22, 2014

Answer:

Please keep in mind the esophageal temperature probe and foley probe may not be recording accurate temperatures. Can also try tympanic membrane, but the probe has to touch the TM. Rectal might be reflective of core, but not always.

Tags:  5041495  esophageal  foley  rectal  temperature  tympanic 

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What is the best syringe/device available to obtain the water from the bag to rapidly draw it out with a syringe to mix it with the dantrolene?

Posted By Administration, Monday, November 24, 2014
Updated: Monday, December 22, 2014

Question:

Dantrolene is hard to mix. We are currently using bags of bacteriostatic free sterile water to mix our dantrolene. It is difficult for us to spike the bag each time and draw it with our 18 gauge needles. What is the best syringe/device available to obtain the water from the bag to rapidly draw it out with a syringe to mix it with the dantrolene?

Answer:

You should use glass vials and not bags because of the possibility of accidentally giving intravenously. There are various spring-loaded syringes that may help with this process. The new dantrolene preparation Ryanodex requires only 5 mL per 250 mg vial.

Tags:  5041495  bacteriostatic  dantrolene  glass vials  mixing  water 

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