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Posted By Michael Wesolowski,
Thursday, April 3, 2014
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The Inaugural Geoffrey Keller Memorial Open Water Swim Held in honor of the late son of Curt and Kathy Keller to support Malignant Hyperthermia awareness. Presented by Marshall, IL, the Geoff Keller Group of MHAUS, and Illinois Department of Natural Resources.
Please share with people you know in areas near to: Chicago, Cincinnati, Indianapolis, Louisville, and St. Louis. Learn more about Geoffrey Keller: http://my.mhaus.org/group/GeoffKeller Sanctioned by Illinois Masters Swimming Association (ILMSA) for United States Masters Swimming (USMS), Inc. USMS Sanction Number: 214‐W002
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Geoff Keller
illinois
swim
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Posted By Michael Wesolowski,
Thursday, April 3, 2014
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"Eagle Pharmaceuticals' Exclusive Licensor Granted US Patent for Dantrolene in the Treatment of Heat Stroke" on Tuesday, 01 April 2014 08:15
Eagle Pharmaceuticals, Inc. ("Eagle") (NASDAQ:EGRX) announced today that the United States Patent and Trademark Office has granted Patent No. 8,685,460 for the treatment of heat stroke with Eagle’s dantrolene sodium for injectable suspension (“dantrolene”). The patent issued today expires in 2023. Eagle’s dantrolene formulation for the treatment of Exertional Heat Stroke (EHS) was granted Orphan Drug designation by the Food and Drug Administration on September 25, 2012.
Eagle is currently developing dantrolene in this new EHS indication. The company filed an NDA in January 2014 for Ryanodex® (dantrolene sodium-for injectable suspension) in the treatment of Malignant Hyperthermia (“MH”) which was granted a priority review and has a PDUFA date of July 22, 2014. Ryanodex for the treatment of MH has also received Orphan Drug designation.
EHS is one of the top three causes of sudden death among student athletes and is a leading cause of non-combat death within the US Military. Currently, there are no FDA approved drugs for the treatment of EHS. The current standard of care in treating heat stroke patients is aggressive cooling e.g. through icing and intravenous hydration. It is estimated that there are 30,000 cases of heat stroke every year in the US. Scott Tarriff, Eagle’s CEO, said, “This is the fourth patent issued to Eagle regarding Ryanodex. Eagle now has 11 patents owned, licensed or issued covering its pipeline and an additional 10 patents filed with the US patent office.”
ABOUT EXERTIONAL HEAT STROKE
EHS is a state of extreme hyperthermia that occurs when heat generated by exercise in warm climates results in an elevated body temperature (above 104° F) due to failed thermoregulation that occurs when the body produces or absorbs more heat than it dissipates. Extreme temperature elevation and the resulting metabolic crisis can become a medical emergency that can result in disability or death.
Read more at: http://www.eagleus.com/news-media/dantrolene-ehs-patent
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dantrolene
eagle pharmaceuticals
heat stroke
ryanodex
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Posted By Michael Wesolowski,
Thursday, April 3, 2014
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"Far Reaching New Information Concerning the Diagnosis and Management of MH and Exertional Heat Stroke" by Dr. Henry Rosenberg MD, CPE Thursday, March 20, 2014
The views expressed in this posting are mine alone and do not necessarily represent the views of other professionals or Board Members of MHAUS.
A 'NEW' DANTROLENE? In 1979 dantrolene was approved by the FDA for the treatment of Malignant Hyperthermia. Dantrium (dantrolene) was developed by a small company located in upstate New York called Norwich Eaton Pharmaceuticals. Procter & Gamble Company (yes, the soap, detergent and household product company) acquired Norwich Eaton prior to the approval of the drug by the FDA. A major effort led by Mary Elizabeth Kolb, spearheaded the effort resulting in approval of the drug in record time. Dantrolene was instantly embraced by the anesthesia community as it was the only drug that was effective in treating and reversing MH. Many hundreds, if not thousands, of lives have been saved thanks to dantrolene.
EXERTIONAL HEAT STROKE AND MALIGNANT HYPERTHERMIA I and others have often written about the possible relationship between exertional heat stroke (EHS) and MH. There are isolated reports in the literature and presentations at meetings, (which often do not get published) demonstrating that some patients who develop exertional heat stroke harbor genetic changes that are found in MH susceptibles. However, it has been difficult to identify a significant number of patients who developed EHS and then were tested for MH susceptibility either by genetic tests or by the standard caffeine halothane contracture test. A very recent publication in the journal Military Medicine by a group of French investigators associated with the French army who have been studying the problem of MH and heat stroke for several years, demonstrate that 138 of 295 patients (47%) who suffered heat stroke were determined to be MH susceptible, based on the European version of the caffeine halothane contracture test which has been shown to be both highly sensitive and specific in diagnosing MH susceptibility (Sagui et al. Military Medicine 179;342, 2014). Unfortunately, they did not report on the molecular genetics of these patients. In addition, the muscle that was harvested for testing was not from the thigh, which is the agreed-upon standard site. However, several MH testing centers in Europe and the US have demonstrated, with a lesser number of patients, that many who experienced heat stroke also harbor MH related mutations in the ryanodine receptor gene.
Tags:
dantrolene
exertion
heat stroke
henry rosenberg
mhaus blog
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Posted By Michael Wesolowski,
Friday, March 14, 2014
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A MH Conference is being planned to happen in Tampa later this year. If you are interested to receive progress updates or to volunteer to help, please express your interest in the comments.
Thanks!
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2014
mh conference
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Posted By Michael Wesolowski,
Friday, March 14, 2014
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What's on your mind?
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comments
questions
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Posted By Michael Wesolowski,
Monday, July 1, 2013
Updated: Thursday, August 1, 2013
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The MH Let’s Save a Life Mini-Conference at Orlando Health in Orlando Florida was a big success thanks to event co-hosts Orlando Health, Florida Society of PeriAnesthesia Nurses, and Florida Society of Anesthesiologists.
Speakers for the event were MHAUS MH Hotline Consultants Kumar Belani, MD and Tae Kim, MD, and Lisa Groetzner who lost her 6 year-old son to MH in 2010. In addition there were impromptu comments made by Curt Keller a parent who lost his 26 year-old son to MH in 2012 and Heidy Frank a parent diagnosed with MH in Brazil now living in Miami and Heidy Frank’s Mother.
The event was attended by over 100 people who are healthcare professionals, patients and families, and students; 15 of the attendees are members of MHAUS!
People engaged in conversation with each other and with speakers before, during, and after the event. Photos were taken during the event and in front of the MHAUS logo wall and many of the photos were posted to the Florida MH Group at MHAUS.org and to the MHAUS Page on Facebook. There was also one audio interview was made with an RN who is also MHS.
Lisa Groetzner’s presentation framed the day. Attendees were captivated concentrating her spoken words. Both Doctor’s Belani and Kim referred to Lisa Groetzner’s comments throughout their presentations. Dr. Kim defined malignant hyperthermia. Reviewed pathophysiology of malignant hyperthermia, Described the clinical presentation of malignant hyperthermia. Outline the intraoperative and postoperative management of malignant hyperthermia, and review testing for MH susceptibility. He also presented a soon to be published response from The Joint Commission about points in their code that caught the attention of many of healthcare professionals in the room. Dr. Belani talked about ASCs and Office Based Anesthesia, being better prepared for MH, transfer guidelines and protocol now established, availability of Activated Charcoal filters make for more efficient preparation for elective cases. Improvements in simulation methodologies for MH education. Improved understanding between heat stroke and MH. Development of an algorithm for evaluation of rhabdomyolysis. "Awake” (heat & exercise stress) MH multiple underlying genetic variants and predisposition to development of a (triggerable) myopathy and Evaluation of patients with unexplained rhabdomyolysis. The details about genetic test and who should be tested.
The Frank family learned about their MHS in Brazil in the 1980s and now live in Miami and drove to the conference with their five year-old to get answers. They made comments to attendees, spoke to both doctors Belani and Kim, and after the event connected with the MHAUS Patient Liaison Committee.
Nurses sitting in a group in the back of the room said they were overwhelming in a good-way that there was so much content.
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Posted By Michael Wesolowski,
Friday, May 31, 2013
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Hello Florida MH Group looking forward to seeing you at the Malignant Hyperthermia Mini Conference happening at the Orlando Regional Medical Center in Orlando in Florida Saturday June 29.
Below are a few items and links you might be interested in before the event. Become a member: If you are already a member, MHAUS thanks you for your support. MHAUS membership supports programs such as the 24-hour MH Hotline, development of educational and informational materials, articles and papers written by medical professionals from the North American MH Registry of MHAUS and others affiliated with MHAUS, and staff exhibiting and talking with attendees at medical meetings and coordinating this conference and the bi-annual scientific conference and scholarly awards. If you are not a member please consider joining the Malignant Hyperthermia Association of the United States (MHAUS) in continuing to promote optimum care and scientific understanding of Malignant Hyperthermia (MH) and related disorders. MHAUS has been dramatically increasing the odds of patient survival during an MH crisis since 1981. Click here to learn about membership. Let’s Meetup: MHAUS staff is lodging right near the Conference site and would be happy to meet up if you want to talk more. Email: michael@mhaus.org or call or text: 607-316-6271. Please Post to Social Media: Yes please post your comments to Facebook and Twitter about the event during the event! Conference hashtag is: #mhorlando Please Take Photos: Yes please! Take photos during the event for your own reference and to share with MHAUS by email at: photo@mhaus.org Record your MH story: Consider arriving early from 8am to 9am on Saturday morning of the conference to record your connection to MH. Recordings will be posted on the MHAUS website and used to help other people new to MH understand the condition better. Click this link to learn more. Repeat the Conference: If you like the Conference to repeat in Florida in 2014 and 2015 we need your help to consider talking with other conference attendees after the event to . to the repeat the Conference in Florida in 2014 or 2015. The MH Mini The Florida MH Mini Conference is a great way to build MH awareness and offer MH education in Florida at the same time. If you other like-minded people in Florida to offer this conference If you are interested to Consider meeting with me for a few minutes from 8am to 9am on Saturday morning of the link to group: http://my.mhaus.org/group/florida See you there!
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